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Leahy Looks to Slow Surging White Sox as Cardinals Try to Salvage Series in St. Louis

The Cardinals and White Sox meet Saturday night at 7:15 PM ET for Game 2 of their three-game regular-season series, and for St. Louis, this one carries a bit...

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Thursday, September 10, 2026
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The Cardinals and White Sox meet Saturday night at 7:15 PM ET for Game 2 of their three-game regular-season series, and for St. Louis, this one carries a bit of urgency after a rough week. Chicago comes in with momentum on its side, while the Cardinals are trying to stop the bleeding in what's become a difficult September.

St. Louis sits at 72-75 through 147 games, averaging 4.5 runs while allowing 4.6 — a run differential of minus-12 that tells the story of a team treading water. The Cardinals have dropped four of their last five, including a rough three-game stretch against San Francisco (losses of 6-7, 1-2 and 4-5) before splitting a two-game set with Colorado, winning 10-8 and then falling 7-10. It's been a start-and-stall stretch, and with the calendar creeping toward the season's final month, St. Louis needs to find some consistency.

Chicago, meanwhile, is playing like a team with something to prove. The White Sox are 75-69 in 145 games, scoring 4.7 runs per game while allowing 4.4 — a plus-42 run differential that dwarfs anything St. Louis has going. Their recent form has been streaky but productive: losses to Pittsburgh (2-4, 3-9) sandwiched a lopsided 10-1 win over Minnesota, followed by a 4-6 loss and a 4-1 win against the Twins. When this offense gets going, it gets going in a hurry.

Interestingly, the head-to-head history this season heavily favors St. Louis. The Cardinals took all three meetings back in June, including a 2-12 blowout, so there's precedent here for St. Louis finding a way to get under Chicago's skin even in a season where the overall numbers favor the White Sox.

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On the mound, St. Louis hands the ball to Kyle Leahy, who's been the stabilizing force of this rotation with a 3.409 ERA. He'll need to be sharp given the state of the Cardinals' pitching staff, which has been gutted by injury — Max Rajcic and Hunter Dobbins are both out long-term, and the bullpen has taken hits too with Peter Strzelecki sidelined. Leahy's ability to go deep and save the relief corps could be the difference in this game.

Chicago counters with Anthony Kay, who owns a 4.468 ERA and will be looking to bounce back after some shaky recent outings from this rotation, which has its own long list of absences — Ky Bush, Drew Thorpe and several relievers all unavailable. Both teams are essentially playing punch-and-counterpunch with patchwork pitching staffs, which raises the likelihood of another high-scoring affair given the recent form on both sides.

Offensively, St. Louis will lean on whoever's healthy in a lineup missing key pieces. Alec Burleson, Iván Herrera, Masyn Winn and JJ Wetherholt are all out, forcing manager's hand in the middle infield and behind the plate. That puts more weight on Jordan Walker, who's averaging 11.7 fantasy points on the season but has been quiet lately with 0, 0 and 7 points in his last three outings. Nolan Gorman has flashed some pop recently with a 13-point game mixed into his last three, and Victor Scott II has been steady in center, posting 8-point efforts in two of his last three games. Pedro Pagés will factor in behind the plate with Herrera out, though his own production has been inconsistent of late.

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Chicago's lineup is deeper and healthier at the top, even with Miguel Vargas and Munetaka Murakami unavailable. Colson Montgomery leads the White Sox's key names with a 12.6 season average at shortstop, though he's cooled off recently with 0, 3 and 4.5-point games. Chase Meidroth has been up and down at second base, capped by a 12-point showing in his last outing. The most interesting name might be Randal Grichuk, who exploded for 36.5 points two games ago after a modest 9.5, and Tristan Peters, who similarly popped for 35 points sandwiched between quieter nights. When this offense heats up, it can do damage in a hurry, and St. Louis' banged-up pitching staff will be tested.

There are no fantasy projections available for this matchup, so the emphasis here is squarely on form and health. St. Louis' rotation troubles are real, and Chicago's offense has shown flashes of real explosiveness in its last several games, even while dealing with its own significant list of unavailable players.

Given Chicago's superior run differential, healthier top-line offensive production, and the recent power surges from Grichuk and Peters, the White Sox look like the better bet to control this game — even with St. Louis holding the head-to-head edge this season. Expect a competitive, back-and-forth affair that ultimately tilts Chicago's way.

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Prediction: White Sox 7, Cardinals 5.

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